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DEAD, diethylazodicarboxylate; Ph3P, triphenylphosphine; TEA, triethylamine; DCC, dicyclohexylcarbodiimide; DCM, dichloromethane. General methods. N-Fmoc-L-serine and N-Fmoc-L-threonine were purchased from Advanced ChemTech, and DEAD and p-nitrobenzoyl chloride were purchased from Fluka. All other reagents were purchased from Aldrich and were used without further purification unless stated otherwise. Conventional solvents were purchased from Fischer. Tretrahydrofuran (THF) was distilled under nitrogen from sodium/benzophenone. MeOH was dried over molecular sieves or purchased from Acros. Diazomethane was obtained from Diazald (Aldrich) in a 23 mmol scale. Sodium sulfate was used to dry organic layers during work up. Thin-layer chromatography was carried out on E. Merck precoated silica gel 60 F254 plates. E. Merck silica gel 60 (230-400 mesh) was used for flash chromatography. Melting points were determined on a Fisher-Johns melting point apparatus and are uncorrected. Combustion analyses were performed by Oneida Research Laboratories, NY. 1H NMR spectra were recorded on a Gemini 2000, Mercury 400 or Inova 500 spectrometers (75.4, 100.6, or 125.7 MHz, for 13C NMR spectra) in CDCl3. Chemical shifts are reported as values in parts per million relative to TMS in CDCl3. Mass spectra were performed on a Micromass Quattro II spectrometer (APCI, ESI), or on a VG Instrument (VG70-250SE) high-resolution mass spectrometer (EI). Typical procedure for the azide mediated cleavage of the p-nitrobenzoates: N-Fmoc-L-serine (1b). A solution of 1a (200 mg, 0.41 mmol) and sodium azide (133 mg, 1.22 mmol) in dry MeOH (10 mL) was warmed at 40 oC for 14 h under nitrogen. The solvent was removed on a rotary evaporator, and the compound was purified by flash chromatography (DCM:acetone, 10:0.5) to give 133 mg (95%) of a yellowish white solid. For other compounds, the reaction time, temperature, solvent of reaction, equiv of sodium azide, and yield were those indicated in Table 1. The spectral data of the compounds obtained were identical to those of the hydroxy compounds 1b-8b. N-Fmoc-O-(p-nitrobenzoyl)-L-serine methyl ester (1). A solution of diazomethane in ethyl ether was added to a stirred cooled solution of N-Fmoc-L-serine (1.0 g, 3.06 mmol) in methanol until a pale yellow color persisted. The solution was stirred for 15 min at room temperature, and the solvent was removed on a rotary evaporator to give 1.04 g of a yellowish white solid. 1H NMR (300 MHz) d№: 3.75 (s, 3H), 3.86-4.00 (m, 2H), 4.20 (t, 1H), 4.38-4.46 (m, 3H), 5.99 (m, 1H), 7.27-7.41 (m, 4H), 7.58-7.59 (m, 2H), 7.74-7.76 (d, 2H). The compound was used directly in the next reaction without further purification. p-Nitrobenzoyl chloride (0.60 g, 3.22 mmol), was added in one portion to a stirred ice-cooled solution of N-Fmoc-L-serine methyl ester (1.0 g, 2.93 mmol) and TEA (0.45 ml, 3.22 mmol) in dry THF (15 mL) under nitrogen. The reaction was stirred overnight at room temperature. The solvent was removed on the rotary evaporator, and the compound was purified by flash chromatography (DCM:acetone, 10:0.1) to give 1.21 g (84%) of a yellowish white solid. 1H NMR (300 MHz) d№: 3.82 (s, 3H), 4.21 (t, J = 6.8 Hz, 1H), 4.44 (d, J = 6.9 Hz, 2H), 4.66-4.81 (m, 3H), 5.69 (1H, J =7.7 Hz, 1H), 7.29-7.42 (m, 4H), 7.55-7.59 (m, 2H), 7.73-7.77 (m, 2H), 8.15 (d, J = 8.8 Hz, 2H), 8.27 (d, J = 9.1 Hz, 2H). 13C NMR d№: 47.4, 53.3, 53.6, 65.4, 67.5, 120.2, 123.8, 125.2, 127.3, 128.0, 131.1, 134.9, 141.6, 143.8, 151.0, 155.9, 164.4, 169.9. APCI-MS: 310.3, 491.4 ([M+H]+). A sample of this compound was recrystallized from hexanes for analytical purposes. Anal. Calcd. for C26H22N2O8: C, 63.67; H, 4.52; N, 5.71. Found: C, 63.74; H, 4.44; N, 5.70. N-Fmoc-O-(p-nitrobenzoyl)-L-threonine methyl ester (2). A solution of diazomethane in ethyl ether was added to a stirred cooled solution of N-Fmoc-L-threonine (0.50 g, 1.47 mmol) in methanol until a pale yellow color persisted. The solution was stirred for 15 min at room temperature, and the solvent was removed on a rotary evaporator to give 0.52 g of a yellowish white solid. 1H NMR (400 MHz) d№: 1.24 (d, J = 6.0 Hz, 3H), 3.76 (s, 3H), 4.23 (t, 1H), 4.33-4.42 (m, 4H), 5.70 (d, J = 8 Hz, 1H), 7.29-7.41 (m, 4H), 7.61 (t, 2H), 7.76 (d, J = 7.2 Hz, 2H). The compound was used directly in the next reaction without further purification. DMAP (7 mg, 0.06 mmol) was added to a solution of N-Fmoc-L-threonine methyl ester (0.20 g, 0.56 mmol), p-nitrobenzoic acid (103 mg, 0.62 mmol), and DCC (128 mg, 0.62 mmol) in dry THF and allowed to stir for 18 h. The solvent was removed on a rotary evaporator, and the compound was purified by flash chromatography (DCM:MeOH 10:0.05) to give 128 mg (45%) of a yellowish white solid. 1H NMR (400 MHz) d№: 1.44 (d, J = 6.0 Hz, 3H), 3.74 (s, 3H), 4.22 (t, J = 6.6 Hz, 1H), 4.46-4.48 (m, 2H), 4.69 (dd, J = 2.2 Hz, 9.4 Hz, 1H), 5.61-5.64 (m, 2H), 7.30 (t, 2H), 7.40 (t, 2H), 7.58-7.61 (m, 2H), 7.76 (d, J = 7.6 Hz, 2H), 8.14 (d, J = 8.4 Hz, 2H), 8.26 (d, J = 8.4 Hz, 2H). Anal. Calcd. for C27H24N2O8: C, 64.28; H, 4.80; N, 5.55. Found: C, 64.39; H, 4.78; N, 5.55. Benzyl-4-(p-nitrobenzoyloxy)benzoate (3). This compound was prepared from benzyl-4-hydroxybenzoate (1.0 g, 4.38 mmol) according to the synthetic procedure for 1. The compound was purified by flash chromatography (DCM) to give 1.54 g (91%) of a yellowish white solid. 1H NMR (400 MHz) d№: 5.40 (s, 2H), 7.33 (d, J = 8.4 Hz, 2H), 7.36-7.48 (m, 5H), 8.19 (d, J = 8.4 Hz, 2H), 8.38 (s, 4H). EI-MS: 150, 270, 377 ([M]+). mp 116-117 oC. A sample of this compound was recrystallized from acetone for analytical purposes. Anal. Calcd. for C21H15NO6: C, 66.84; H, 4.01; N, 3.71. Found: C, 66.57; H, 3.83; N, 3.75. Benzyl-p-nitrobenzoate (4). DMAP (0.42 g, 3.4 mmol) was added to an iced-cooled solution of benzyl alcohol (0.37 g, 3.4 mmol) and p-nitrobenzoyl chloride (0.58 g, 3.1 mmol) in dry DCM under nitrogen. The temperature was allowed to rise to room temperature, and the reaction was allowed to stir for 24 h. The solvent was removed on a rotary evaporator, and the compound was purified by flash chromatography (DCM) to give 730 mg (92%) of a yellowish white solid. 1H NMR (400 MHz) d№: 5.41 (s, 2H), 7.38-7.45 (m, 5H), 8.23-8.30 (m, 4H). mp 79-80 oC. trans-O-(p-Nitrobenzoyl)-2-phenyl-cyclohexanol (5). This compound was prepared from trans-2-phenyl-1-cyclohexanol (0.86 g, 4.90 mmol) according to the synthetic procedure for 4. The solvent was removed on a rotary evaporator, and the crude was dissolved in DCM, extracted with water, and 10% acetic acid. The organic layer was dried over magnesium sulfate, and the solvent was removed on a rotary evaporator. The compound was purified by flash chromatography (DCM) to give 1.28 g (89%) of a yellowish white solid. 1H NMR (400 MHz) d№: 1.38-1.72 (m, 3H), 1.84-2.04 (m, 4H), 2.28-2.31 (m, 1H), 2.82-2.89 (m, 1H), 5.16-5.23 (m, 1H), 7.10-7.16 (m, 1H), 7.2-7.26 (m, 4H), 7.93 (d, J = 8.8Hz, 2H), 8.17 (d, J = 8.8 Hz, 2H). mp 104-105 oC. A sample of this compound was recrystallized from hexanes for analytical purposes. Anal. Calcd. for C19H19NO4: C, 70.14; H, 5.89; N, 4.31. Found: C, 70.49; H, 5.70; N, 4.31. cis-O-(p-Nitrobenzoyl)-2-phenyl-cyclohexanol (6). DEAD (0.5 mL, 3.17 mmol) was added slowly via syringe to a stirred ice-cooled solution of trans-2-phenyl-1-cyclohexanol (373 mg, 2.12 mmol), p-nitrobenzoic acid (530 mg, 3.17 mmol), and Ph3P (831 mg, 3.17 mmol) in dry THF under nitrogen. The temperature was allowed to rise to room temperature. After 22 h the solvent was removed on a rotary evaporator, and the compound was purified by flash chromatography (DCM:hexanes, 1:1) to give 0.57 g (85%) of a yellowish white solid. 1H NMR (400 MHz) d№: 1.50-1.70 (m, 3H), 1.74-1.82 (m, 1H), 1.88-1.94 (m, 1H), 2.0-2.04 (m, 1H), 2.18-2.28 (m, 2H), 2.93-2.96 (m, 1H), 5.47 (br s, 1H), 7.22-7.26 (m, 5H), 8.12 (d, J = 8.2 Hz, 2H), 8.27 (d, J = 8.2 Hz, 2H). EI-MS: 158.1, 325.1 ([M]+). mp 118-119 oC. A sample of this compound was recrystallized from hexanes for analytical purposes. Anal. Calcd. for C19H19NO4: C, 70.14; H, 5.89; N, 4.31. Found: C, 70.20; H, 5.70; N, 4.33. O-(p-Nitrobenzoyl)-1-ethynylcyclohexanol (7). This compound was prepared from 1-ethynylcyclohexanol (1.2 g, 9.66 mmol) according to the synthetic procedure for 4. The compound was purified by flash chromatography (DCM:hexanes, 2:1) to give 2.2 g (92%) of a yellowish white solid. 1H NMR (500 MHz) d№: 1.40-1.46 (m, 2H), 1.68-1.76 (m, 4H), 2.04-2.10 (m, 2H), 2.24-2.30 (m, 2H), 2.70 (s, 1H), 8.20 (d, J = 8.5 Hz, 2H), 8.29 (d, J = 8.5 Hz, 2H). EI-MS: 150, 273.1 ([M]+). mp 62-63 oC. O-(p-Nitrobenzoyl)-(-)-menthol (8). This compound was prepared from (-)-menthol (0.50 g, 3.20 mmol) according to the synthetic procedure for 1. The compound was purified by flash chromatography (DCM) to give 0.66 g (70%) of a yellowish white solid. 1H NMR (500 MHz) d№: 0.80 (d, J = 7.0 Hz, 3H), 0.9-0.99 (m, 7H), 1.10-1.19 (m, 2H), 1.54-1.62 (m, 2H), 1.73-1.78 (m, 2H), 1.89-1.95 (m, 1H), 2.11-2.15 (m, 1H), 4.98 (ddd, J = 4.3 Hz, 10.9 Hz, 1H), 8.21 (d, J = 9.0 Hz, 2H), 8.28 (d, J= 9.0 Hz, 2H). 13C NMR d№: 16.7, 20.9, 22.2, 23.8, 26.8, 31.7, 34.4, 41.1, 47.2, 76.4, 123.7, 130.9, 136.4, 150.7, 164.4. O-(p-Nitrobenzoyl)-2-phenyl-2-propanol (9). This compound was prepared from 2-phenyl-2-propanol (1.06 g, 7.76 mmol) according to the synthetic procedure for 4. The compound was purified by flash chromatography (DCM:hexanes, 1:1) to give 1.61 g (87%). 1H NMR (500 MHz) d№: 1.95 (s, 6H), 7.29 (t, 1H), 7.36 (t, 2H), 7.43 (d, J = 7.50 Hz, 2H), 8.19 (d, J = 8.5 Hz, 2H), 8.28 (d, J = 8.5 Hz, 2H). EI- MS: 163, 285.1 ([M]+). mp 126-127 oC. A sample of this compound was recrystallized from hexanes for analytical purposes. Anal. Calcd. for C16H15NO4: C, 67.37; H, 5.30; N, 4.91. Found: C, 66.99; H, 5.38; N, 4.87. Ethyl N-(p-nitrobenzoyl)-3-aminopropionate (10). This compound was prepared from ethyl 3-aminopropionate (0.20 g, 1.3 mmol) according to the synthetic procedure for 1. The compound was purified by flash chromatography (DCM) to give 259 mg (84%) of a yellowish white solid. 1H NMR (400 MHz) d№: 1.28 (t, 3H), 2.68 (t, 2H), 3.76 (c, 2H), 4.19 (c, 2H), 7.13 (br s, 1H), 7.94 (d, 2H), 8.29 (d, 2H). EI MS: 116.1, 150, 266.1 ([M]+). mp 84-85 oC. N-(Trifluoroacetyl)-3-methylbenzylamine (11). A solution of 3-methylbenzylamine (0.1 mL, 0.8 mmol) and (trifluoroacetyl)benzotriazole (342 mg, 1.6 mmol) in dry THF (5 mL) was stirred at room temperature under nitrogen overnight. The solvent was removed on a rotary evaporator. The crude product was dissolved in DCM and washed with 10% NaOH, and water. The organic layer was dried over sodium sulfate, and the solvent was removed to give 0.17 g (quantitative) of a thick colorless oil. 1H NMR (300 MHz) d№: 2.36 (s, 3H), 4.89 (br s, 2H), 7.08-7.29 (m, 4H).  Katritzky, A. R; Yang, B.; Semenzin, D. J. Org. 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